Investigating how certain proteins help botulinum neurotoxins function in the body
Structural studies of the OrfX-type progenitor toxin complex of botulinum neurotoxin
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11140224
This study is looking at how certain proteins help a type of botulinum toxin work better in the body, which could lead to improved treatments for medical and cosmetic uses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11140224 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the structural properties of a specific type of botulinum neurotoxin complex produced by Clostridium bacteria. It aims to explore how non-toxic proteins associated with these neurotoxins protect them and facilitate their absorption in the gastrointestinal tract. By studying these interactions, the research seeks to uncover mechanisms that could improve therapeutic applications of botulinum neurotoxins, which are already used in various medical and aesthetic treatments. The approach involves detailed structural and functional analyses of the toxin complexes to better understand their biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals undergoing treatments involving botulinum neurotoxins or those affected by conditions related to botulism.
Not a fit: Patients who do not use or require botulinum toxin treatments or who have no history of botulism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the safety and efficacy of botulinum toxin treatments, potentially leading to improved therapies for conditions treated with these neurotoxins.
How similar studies have performed: Previous research has shown success in understanding other types of botulinum toxin complexes, but the specific focus on the OrfX-type progenitor toxin complex is relatively novel.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIN, RONGSHENG — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: JIN, RONGSHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.