Investigating how certain proteins from a fungus interact with the immune system.
Role of secreted cystine-knot proteins in Histoplasma-host interactions
This study is looking at a fungus that can make people sick, and the researchers want to learn more about certain proteins it produces that help it survive in our immune cells, which could lead to better ways to treat infections caused by this fungus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11021080 on NIH RePORTER |
What this research studies
This research focuses on the fungus Histoplasma capsulatum, which can cause infections in humans. The team is studying specific proteins produced by this fungus that may help it survive and thrive within immune cells. By analyzing how these proteins function and their role in the infection process, the researchers aim to uncover new insights into the mechanisms of fungal virulence. This could lead to better understanding and potential treatments for infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Histoplasma infections or are at high risk for such infections.
Not a fit: Patients who do not have a history of fungal infections or are not at risk for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating infections caused by Histoplasma capsulatum.
How similar studies have performed: Previous research has shown success in understanding fungal virulence mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Sil, Anita — University of California, San Francisco
- Study coordinator: Sil, Anita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.