Investigating how certain proteins from a fungus interact with the immune system.
Official title: Role of secreted cystine-knot proteins in Histoplasma-host interactions
Funded at University of California, San Francisco · NIH-11021080 · Data updated 2026-11-12
This study is looking at a fungus that can make people sick, and the researchers want to learn more about certain proteins it produces that help it survive in our immune cells, which could lead to better ways to treat infections caused by this fungus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $567,183 |
| NIH project number | 5R01AI172258-03 |
| Project ID | NIH-11021080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Histoplasma infections or are at high risk for such infections.
✕Less likely to help
Patients who do not have a history of fungal infections or are not at risk for such infections may not benefit from this research.
What this research studies
This research focuses on the fungus Histoplasma capsulatum, which can cause infections in humans. The team is studying specific proteins produced by this fungus that may help it survive and thrive within immune cells. By analyzing how these proteins function and their role in the infection process, the researchers aim to uncover new insights into the mechanisms of fungal virulence. This could lead to better understanding and potential treatments for infections caused by this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating infections caused by Histoplasma capsulatum.
How similar studies have gone: Previous research has shown success in understanding fungal virulence mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Sil, Anita — University of California, San Francisco
- Study coordinator: Sil, Anita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.