Investigating how certain proteins control inflammatory cell death
Cellular Engineering to identify gasdermin protein networks regulating inflammatory cell death
This study is looking at a special kind of cell death called pyroptosis, which happens during infections and inflammation, to see how a protein named Gasdermin D helps our immune system respond, and it hopes to find new ways our body can handle inflammation and fight off infections if this process doesn't work properly.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10861065 on NIH RePORTER |
What this research studies
This research focuses on understanding a specific type of cell death called pyroptosis, which is triggered by infections and inflammation. It examines how proteins, particularly Gasdermin D, are involved in this process and how they help the immune system respond to threats. By studying the mechanisms behind pyroptosis, the researchers aim to uncover alternative pathways that may be activated when this process is blocked. This could lead to new insights into how the body manages inflammation and fights infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve excessive inflammation or infections.
Not a fit: Patients with stable, non-inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response to infections and inflammatory diseases.
How similar studies have performed: Other research has shown promise in understanding cell death mechanisms, but this specific approach to studying Gasdermin networks is relatively novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Abbott, Derek W — Case Western Reserve University
- Study coordinator: Abbott, Derek W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.