Investigating how certain proteins contribute to chronic airway diseases like asthma and COPD
Non-Classical Cytokine Secretion in Chronic Airway Disease
This study is looking at how certain proteins in the airways might contribute to asthma and COPD, with the goal of finding new ways to help improve treatments for people living with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10875645 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind chronic airway diseases, particularly asthma and COPD, by examining the role of specific proteins secreted by airway cells. Researchers will study how these proteins, especially a variant of IL-33, are activated and released from diseased cells, potentially leading to inflammation. The study involves both human clinical samples and animal models to gather comprehensive data on these processes. By identifying new pathways for therapeutic intervention, the research aims to improve treatment options for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with asthma or COPD, particularly those experiencing severe symptoms or complications.
Not a fit: Patients with mild respiratory issues or those without a diagnosis of asthma or COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that more effectively target the underlying causes of asthma and COPD.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in chronic airway diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Alexander-Brett, Jennifer — Washington University
- Study coordinator: Alexander-Brett, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.