Investigating how certain proteins communicate signals in cells
Structural and biochemical studies of receptor tyrosine kinases
['FUNDING_OTHER'] · NORTHPORT VA MEDICAL CENTER · NIH-10951537
This study is looking at how certain proteins help cells communicate and grow, especially focusing on how insulin and a similar protein called IGF1 work together, which could help us understand diseases like diabetes and cancer better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHPORT VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (NORTHPORT, UNITED STATES) |
| Trial ID | NIH-10951537 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding receptor tyrosine kinases (RTKs), which are crucial for cell communication and regulation of growth and metabolism. The study aims to explore how insulin and insulin-like growth factor-1 (IGF1) activate these receptors and how they interact with other signaling proteins. By using advanced techniques like cryo-electron microscopy, researchers will visualize the structures of these receptors and their associated proteins. This could lead to a better understanding of the mechanisms behind various diseases, including diabetes and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with adult-onset diabetes or related metabolic disorders.
Not a fit: Patients with conditions unrelated to receptor tyrosine kinases or those not affected by insulin signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions like diabetes and certain cancers by enhancing our understanding of cell signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding RTKs and their roles in cell signaling, indicating that this approach has potential for significant findings.
Where this research is happening
NORTHPORT, UNITED STATES
- NORTHPORT VA MEDICAL CENTER — NORTHPORT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, W TODD — NORTHPORT VA MEDICAL CENTER
- Study coordinator: MILLER, W TODD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus