Investigating how certain proteins are modified and retained on bacterial surfaces
Official title: Post-translational modification of GlyGly-Cterm Proteins
Funded at University of Michigan at Ann Arbor · NIH-10906663 · Data updated 2026-11-12
This study is looking at how a specific part of certain bacteria, like Vibrio cholerae, helps keep proteins on their surface, which is important for how these bacteria adapt, especially in relation to cholera.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $79,984 |
| NIH project number | 5F32AI178852-02 |
| Project ID | NIH-10906663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients in impoverished or destabilized regions who are at risk of cholera or similar bacterial infections would be ideal candidates to benefit from this research.
✕Less likely to help
Patients with non-bacterial gastrointestinal issues or those not affected by cholera may not receive any benefit from this research.
What this research studies
This research focuses on understanding how the GlyGly-Cterm domain in certain bacteria, particularly Vibrio cholerae, affects the retention of proteins on the bacterial surface. By using a model protein called VesB, the study will explore the molecular requirements for this retention process through techniques like fluorescence microscopy and cell fractionation. The research aims to identify the enzymes involved in processing these proteins and their significance in bacterial adaptation, particularly in the context of cholera.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cholera and other bacterial infections.
How similar studies have gone: Previous research has shown success in understanding bacterial secretion systems, but the specific focus on the GlyGly-Cterm domain is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Roberts, Cameron — University of Michigan at Ann Arbor
- Study coordinator: Roberts, Cameron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.