Investigating how certain proteins are broken down in cells to help treat age-related diseases.
Endocytosis and Endolysosomal Trafficking of Receptor Tyrosine Kinases in the Regulation of Chaperone-Mediated Autophagy
This study is looking at a process in our cells that helps get rid of certain proteins, and by figuring out how to boost this process, the researchers hope to find new treatments that could help with age-related diseases like Alzheimer's and Parkinson's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11219820 on NIH RePORTER |
What this research studies
This research focuses on chaperone-mediated autophagy (CMA), a process that selectively degrades specific proteins in cells. By understanding how CMA is regulated, particularly through certain receptors involved in insulin and growth factor signaling, the researchers aim to find new ways to activate this process therapeutically. This could potentially help manage or prevent age-related diseases such as Alzheimer's and Parkinson's. The study involves both laboratory experiments and potential drug interventions to enhance CMA activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with age-related diseases like Alzheimer's or Parkinson's.
Not a fit: Patients with acute conditions unrelated to age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or manage age-related diseases by improving the body's ability to degrade harmful proteins.
How similar studies have performed: Previous research has shown promise in activating CMA through various signaling pathways, indicating potential for success in this approach.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Endicott, Samuel Joseph — University of New Mexico Health Scis Ctr
- Study coordinator: Endicott, Samuel Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.