Investigating how certain proteins affect viral chromatin and gene regulation
Studies on Epigenetically Active Latent Chromatin Maintenance
This study is looking at how a specific protein complex helps keep the Kaposi's sarcoma-associated herpesvirus in a dormant state, which could lead to new treatments for viral infections and related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11011464 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms behind the regulation of viral chromatin, specifically how a protein complex interacts with viral elements to maintain their latent state. By studying the Kaposi's sarcoma-associated herpesvirus (KSHV) and its interactions with host proteins, the research aims to uncover how these interactions influence gene expression and viral behavior. The approach includes advanced techniques in transcriptomics, genomics, and proteomics to analyze these complex biological processes. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting viral infections and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers related to viral infections, such as those with Kaposi's sarcoma or other related conditions.
Not a fit: Patients with non-viral related cancers or those not affected by viral infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for cancers associated with viral infections by targeting the mechanisms that control viral latency.
How similar studies have performed: Other research has shown promise in targeting viral latency mechanisms, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Izumiya, Yoshihiro — University of California at Davis
- Study coordinator: Izumiya, Yoshihiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.