Investigating how certain proteins affect the progression of melanoma
Targeting Rheostatic Mechanisms of Melanoma Progression
This study is looking at how a protein called ARF6 affects the growth and spread of melanoma, especially in patients with a specific mutation, to find new ways to treat this aggressive skin cancer and help improve outcomes for those affected.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10884247 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind melanoma, a highly aggressive skin cancer. It specifically examines the role of the ARF6 protein in the development and spread of melanoma, particularly in cases with the BRAFV600E mutation. By using advanced techniques like CRISPR, the researchers aim to uncover how ARF6 influences tumor growth and metastasis. The goal is to identify new therapeutic strategies that can overcome current treatment limitations and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with melanoma, particularly those with the BRAFV600E mutation, across all age groups.
Not a fit: Patients with non-melanoma skin cancers or those without the BRAFV600E mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new combination therapies that effectively limit melanoma progression and improve survival rates.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in melanoma, indicating that this approach may lead to significant advancements.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Grossmann, Allie H. — University of Utah
- Study coordinator: Grossmann, Allie H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.