Investigating how certain proteins affect the development and survival of brain cells involved in myelin production.
SNARE complex-mediated exocytosis in oligodendrocyte differentiation and survival
This study is looking at how certain proteins help brain cells called oligodendrocytes grow and survive, which is important for repairing the protective covering around nerves, and it aims to find new ways to help people with conditions like multiple sclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10813083 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of SNARE proteins in the differentiation and survival of oligodendrocytes, which are crucial for myelination in the brain. It aims to uncover how oligodendrocyte precursor cells (OPCs) respond to neuronal activity and the mechanisms that lead to their maturation into myelinating oligodendrocytes. By studying the signaling pathways and cellular interactions involved, the research seeks to identify potential therapeutic targets for improving remyelination in conditions like multiple sclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis or other demyelinating disorders.
Not a fit: Patients with non-demyelinating neurological conditions or those who do not have oligodendrocyte-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance remyelination and improve neurological function in patients with demyelinating diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular mechanisms in myelination, suggesting that this approach could yield valuable insights.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Nishiyama, Akiko — University of Connecticut Storrs
- Study coordinator: Nishiyama, Akiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.