Investigating how certain proteins affect sperm development in a model organism.
Official title: Post-translational regulation of sperm development and function in C. elegans
Funded at College of William and Mary · NIH-10653491 · Data updated 2026-11-12
This study is looking at how certain proteins help sperm develop and work in tiny worms called C. elegans, which can teach us more about similar processes in humans and might even help find new treatments for diseases like Alzheimer's, cancer, and parasitic infections.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of William and Mary NIH-funded |
| Lab location | 1 site (Williamsburg, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $412,150 |
| NIH project number | 1R15GM150079-01 |
| Project ID | NIH-10653491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals affected by Alzheimer's disease or related conditions, as well as those interested in fertility treatments.
✕Less likely to help
Patients with conditions unrelated to the cellular mechanisms being studied, such as acute infections or non-genetic disorders, may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins, kinases, and phosphatases, in the development and function of sperm in the model organism C. elegans. By studying these proteins, which are also relevant to human diseases like Alzheimer's and cancer, the research aims to uncover fundamental biological processes that could inform future treatments. The unique characteristics of C. elegans, including its transparent body, allow for real-time observation of sperm behavior, providing valuable insights into cellular functions. The findings may also lead to potential drug targets for treating parasitic infections affecting humans.
Why it matters
Potential benefit: If successful, this research could lead to new insights into fertility and potential treatments for diseases like Alzheimer's and cancer.
How similar studies have gone: While the specific approach of using C. elegans for studying these proteins is innovative, similar research has shown promise in understanding cellular processes relevant to human health.
Where this research is happening
-
College of William and Mary
Williamsburg, United States Active
Researchers
- Principal investigator: Shakes, Diane Carol — College of William and Mary
- Study coordinator: Shakes, Diane Carol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.