Investigating how certain proteins affect nerve function
The Role of ESCRTs in Regulating Nervous System Function
This study is looking at how certain proteins affect nerve cells and their helpers, called Schwann cells, to find new ways to improve nerve function for people with conditions like Charcot-Marie-Tooth disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10749928 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific proteins in the nervous system, particularly how they influence Schwann cells, which are crucial for nerve insulation and function. By studying the NRG1/ERBB signaling pathway, the research aims to uncover mechanisms that could restore nerve function in conditions like Charcot-Marie-Tooth disease. The approach involves using mouse models and cell cultures to explore how these proteins interact and regulate nerve health. Patients may benefit from insights that could lead to new treatments for peripheral neuropathies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inherited peripheral neuropathies, such as Charcot-Marie-Tooth disease.
Not a fit: Patients with peripheral neuropathies caused by non-genetic factors or unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve nerve function and reduce pain for patients with peripheral neuropathies.
How similar studies have performed: Previous research has shown promise in modulating the NRG1/ERBB signaling pathway in rodent models, indicating potential for success in similar approaches.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Wilson, Scott Michael — University of Alabama at Birmingham
- Study coordinator: Wilson, Scott Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.