Investigating how certain proteins affect metabolism and immune response in tuberculosis
Sirtuins and Host Metabolism in TB Pathogenesis and Treatment
This study is looking at how certain proteins in your immune cells change when you have tuberculosis (TB) and how these changes can affect inflammation and the severity of the disease, with the goal of finding new ways to help improve treatment for TB patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10816617 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of sirtuins, a family of proteins, in the metabolism and immune response of patients with tuberculosis (TB). It examines how Mycobacterium tuberculosis infection alters the function of these proteins in immune cells, leading to increased inflammation and disease severity. By analyzing the metabolic changes in these cells, the research aims to identify potential therapeutic targets that could improve treatment outcomes for TB patients. The approach includes laboratory studies using infected immune cells to explore the underlying mechanisms of TB pathogenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those experiencing severe symptoms or complications.
Not a fit: Patients with non-infectious lung diseases or those who have not been diagnosed with tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the immune response and reduce lung damage in TB patients.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in infectious diseases, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Kornfeld, Hardy — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kornfeld, Hardy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.