Investigating how certain proteins affect memory in Alzheimer's disease
Official title: Structure and function of mammalian CPEB2 aggregates in normal and AD brain
Funded at Stowers Institute for Medical Research · NIH-11052484 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain affect memory and how these proteins change in people with Alzheimer's disease, hoping to find new ways to understand and improve memory in those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | January 15, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $374,503 |
| NIH project number | 5R01AG066189-05 |
| Project ID | NIH-11052484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 25-50 who are undergoing tissue removal for medical reasons related to their condition.
✕Less likely to help
Patients with advanced Alzheimer's disease or those not undergoing tissue removal procedures may not benefit from this research.
What this research studies
This research aims to understand the molecular basis of memory and how it is altered in Alzheimer's disease (AD). The team will focus on a specific family of proteins called CPEB, which are known to stabilize memory in various organisms. By using advanced techniques like cryo-electron microscopy, they will analyze brain tissue from individuals with AD to explore the structure and function of CPEB aggregates. This could provide insights into the contrasting roles of amyloid proteins in memory formation and disruption.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing memory and treating Alzheimer's disease.
How similar studies have gone: While the approach of studying CPEB proteins is innovative, similar research has shown promise in understanding the role of amyloids in memory, suggesting potential for success.
Where this research is happening
-
Stowers Institute for Medical Research
Kansas City, United States Active
Researchers
- Principal investigator: Si, Kausik — Stowers Institute for Medical Research
- Study coordinator: Si, Kausik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.