Investigating how certain proteins affect memory in Alzheimer's disease
Structure and function of mammalian CPEB2 aggregates in normal and AD brain
['FUNDING_R01'] · STOWERS INSTITUTE FOR MEDICAL RESEARCH · NIH-11052484
This study is looking at how certain proteins in the brain affect memory and how these proteins change in people with Alzheimer's disease, hoping to find new ways to understand and improve memory in those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STOWERS INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11052484 on ClinicalTrials.gov |
What this research studies
This research aims to understand the molecular basis of memory and how it is altered in Alzheimer's disease (AD). The team will focus on a specific family of proteins called CPEB, which are known to stabilize memory in various organisms. By using advanced techniques like cryo-electron microscopy, they will analyze brain tissue from individuals with AD to explore the structure and function of CPEB aggregates. This could provide insights into the contrasting roles of amyloid proteins in memory formation and disruption.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 25-50 who are undergoing tissue removal for medical reasons related to their condition.
Not a fit: Patients with advanced Alzheimer's disease or those not undergoing tissue removal procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing memory and treating Alzheimer's disease.
How similar studies have performed: While the approach of studying CPEB proteins is innovative, similar research has shown promise in understanding the role of amyloids in memory, suggesting potential for success.
Where this research is happening
KANSAS CITY, UNITED STATES
- STOWERS INSTITUTE FOR MEDICAL RESEARCH — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SI, KAUSIK — STOWERS INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: SI, KAUSIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.