Investigating how certain proteins affect memory formation in the brain.
Official title: Effectors of presynaptic cAMP dependent potentiation at mossy fiber synapses
Funded at Northwestern University at Chicago · NIH-11133235 · Data updated 2026-11-12
This study is looking at how certain brain processes help us remember things better, especially in people with memory issues like Alzheimer's, to find new ways to improve memory and create better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $77,693 |
| NIH project number | 3R01MH130428-03S1 |
| Project ID | NIH-11133235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or other forms of dementia.
✕Less likely to help
Patients with memory issues not related to Alzheimer's disease or those with advanced stages of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms that enhance memory formation and retrieval in the hippocampus, particularly through the study of presynaptic cAMP-dependent potentiation at mossy fiber synapses. By employing advanced techniques such as proteomics, biochemistry, and electrophysiology, the researchers aim to identify the signaling partners of specific proteins involved in memory processes. This could lead to insights into how memories are formed and maintained, which is crucial for conditions like Alzheimer's disease. Patients may benefit from a deeper understanding of memory-related disorders and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory function in patients with Alzheimer's disease and other memory-related disorders.
How similar studies have gone: Previous research has shown promising results in understanding synaptic plasticity and memory formation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Contractor, Anis — Northwestern University at Chicago
- Study coordinator: Contractor, Anis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.