Investigating how certain proteins affect memory formation in the brain.
Effectors of presynaptic cAMP dependent potentiation at mossy fiber synapses
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11133235
This study is looking at how certain brain processes help us remember things better, especially in people with memory issues like Alzheimer's, to find new ways to improve memory and create better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11133235 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular mechanisms that enhance memory formation and retrieval in the hippocampus, particularly through the study of presynaptic cAMP-dependent potentiation at mossy fiber synapses. By employing advanced techniques such as proteomics, biochemistry, and electrophysiology, the researchers aim to identify the signaling partners of specific proteins involved in memory processes. This could lead to insights into how memories are formed and maintained, which is crucial for conditions like Alzheimer's disease. Patients may benefit from a deeper understanding of memory-related disorders and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or other forms of dementia.
Not a fit: Patients with memory issues not related to Alzheimer's disease or those with advanced stages of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory function in patients with Alzheimer's disease and other memory-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic plasticity and memory formation, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONTRACTOR, ANIS — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CONTRACTOR, ANIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome