Investigating how certain proteins affect memory formation in the brain.
Effectors of presynaptic cAMP dependent potentiation at mossy fiber synapses
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10895493
This study is looking at how certain proteins in the brain help us remember things better, which could lead to new ways to treat or prevent memory problems like Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10895493 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular mechanisms that enhance memory formation and retrieval in the hippocampus, particularly through the role of cAMP-dependent signaling pathways. By examining the interactions of specific proteins involved in synaptic plasticity, the study aims to uncover how these processes contribute to the integrity of episodic memories. Patients may benefit from insights gained into how memory-related conditions, such as Alzheimer's disease, could be treated or prevented. The research employs advanced techniques including proteomics and electrophysiology to explore these complex biological interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or other memory-related disorders.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory function in patients with Alzheimer's disease and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding synaptic plasticity and its implications for memory, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONTRACTOR, ANIS — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CONTRACTOR, ANIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome