Investigating how certain proteins affect macrophages in fighting cancer cells.
Official title: Non-receptor protein tyrosine phosphatases in macrophage-mediated cancer cell phagocytosis.
Funded at Beckman Research Institute/city of Hope · NIH-11035163 · Data updated 2026-11-12
This study is looking at how certain proteins can help immune cells called macrophages better find and destroy cancer cells, with the hope of improving treatments for cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,645 |
| NIH project number | 5R21CA280317-02 |
| Project ID | NIH-11035163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from enhanced immunotherapy approaches.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancer is not responsive to immunotherapy may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of non-receptor protein tyrosine phosphatases in enhancing the ability of macrophages, a type of immune cell, to engulf and destroy cancer cells. By exploring the mechanisms that cancer cells use to evade detection and destruction by macrophages, the study aims to identify ways to block these protective signals. The approach involves examining how manipulating specific proteins can improve macrophage function in targeting and eliminating cancer cells, potentially leading to more effective cancer immunotherapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune system's ability to fight cancer, improving treatment outcomes for patients.
How similar studies have gone: Previous research has shown promising results in enhancing macrophage activity against cancer cells through similar immunotherapeutic approaches.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Feng, Mingye — Beckman Research Institute/city of Hope
- Study coordinator: Feng, Mingye
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.