Investigating how certain proteins affect lung inflammation in sepsis
Role of heme and PGP matrikines in lung inflammation
This study is looking at how certain proteins in the body might cause lung problems during sepsis, with the hope of finding new ways to help people who have lung issues related to this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10693865 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific proteins, particularly proline-glycine-proline (PGP) and heme, in causing inflammation and increased permeability in the lungs during sepsis. The researchers will explore how these proteins interact and contribute to lung injury, using both human and animal models. By examining the mechanisms that regulate the formation of PGP and its effects on lung function, the study aims to identify potential new therapeutic targets for treating acute lung injury. Patients may benefit from insights gained that could lead to improved treatments for lung-related complications in sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients experiencing sepsis-related acute lung injury.
Not a fit: Patients with lung conditions unrelated to sepsis or those not critically ill may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce lung inflammation and improve survival rates in critically ill patients with sepsis.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory mediators in lung injury, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Patel, Rakesh P. — University of Alabama at Birmingham
- Study coordinator: Patel, Rakesh P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.