Investigating how certain proteins affect liver damage from workplace chemicals
Official title: Modulation of RNA Binding Proteins in Xenobiotic-induced Hepatotoxicity
Funded at North Carolina State University Raleigh · NIH-11000639 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies can help protect the liver from damage caused by harmful chemicals we might encounter at work, which is especially important for people dealing with liver issues from chemical exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | January 22, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $459,895 |
| NIH project number | 7R01ES033709-02 |
| Project ID | NIH-11000639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with liver conditions linked to exposure to harmful chemicals in their workplace.
✕Less likely to help
Patients with liver diseases not associated with chemical exposure may not benefit from this research.
What this research studies
This research focuses on understanding how specific RNA binding proteins influence liver damage caused by exposure to harmful workplace chemicals. It examines the role of these proteins in regulating inflammation and fibrosis in the liver, which can lead to severe conditions like liver failure and cancer. By studying the effects of chemicals such as carbon tetrachloride and chlorpyrifos, the research aims to uncover mechanisms that could help mitigate liver damage. Patients with liver conditions related to chemical exposure may find this research particularly relevant.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver damage caused by occupational exposures.
How similar studies have gone: Previous research has shown that targeting RNA binding proteins can influence inflammation and fibrosis, suggesting potential for success in this area.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Saini, Yogesh — North Carolina State University Raleigh
- Study coordinator: Saini, Yogesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.