Investigating how certain proteins affect liver damage from alcohol and fat tissue health.
Official title: Redox Signaling and AMPK Crosstalk on Alcohol-Induced Multi-Organ Damage: Liver and Adipose TIssue
Funded at University of Nebraska Medical Center · NIH-10804261 · Data updated 2026-11-12
This study is looking at how two proteins, SOD1 and AMPK, work together to help protect the liver from damage caused by drinking alcohol, with the hope of finding new ways to prevent or manage liver problems for people who drink.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $374,081 |
| NIH project number | 1R01AA030793-01A1 |
| Project ID | NIH-10804261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with alcohol-related liver disease or those at risk of developing such conditions.
✕Less likely to help
Patients who do not consume alcohol or have no liver-related health issues may not benefit from this research.
What this research studies
This research aims to explore the interactions between specific proteins that may protect the liver from damage caused by alcohol consumption. It focuses on understanding how superoxide dismutase 1 (SOD1) and adenosine monophosphate-activated protein kinase (AMPK) work together to mitigate liver injury and improve fat tissue function. The study will utilize various scientific techniques to manipulate these proteins in liver and fat cells, with the goal of developing new therapies to reduce alcohol-related liver disease. Patients may benefit from insights gained about how to better manage or prevent liver damage associated with alcohol use.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the liver from alcohol-induced damage and improve overall metabolic health.
How similar studies have gone: Previous research has shown promising results in understanding the protective roles of SOD1 in liver health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Viswanathan, Saraswathi — University of Nebraska Medical Center
- Study coordinator: Viswanathan, Saraswathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.