Investigating how certain proteins affect liver and gastrointestinal cell growth due to alcohol.
Official title: Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation
Funded at Feinstein Institute for Medical Research · NIH-10801085 · Data updated 2026-11-12
This study is looking at how certain proteins in the body affect liver damage from drinking alcohol and fat buildup in the liver, using specially modified mice to help find new ways to keep our livers healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $443,383 |
| NIH project number | 2R01AA023146-18A1 |
| Project ID | NIH-10801085 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with alcohol-related liver disease or those at risk due to genetic factors like ALDH2 deficiency.
✕Less likely to help
Patients with liver diseases unrelated to alcohol or metabolic factors may not benefit from this research.
What this research studies
This research focuses on understanding the roles of beta spectrin and SMAD proteins in alcohol-related liver disease and nonalcoholic steatohepatitis. By studying genetically modified mice, the researchers aim to uncover how disruptions in these proteins contribute to liver damage and metabolic disorders caused by alcohol consumption. The approach involves examining the effects of these proteins on liver cell proliferation and the metabolism of alcohol and lipids, which could lead to new insights into liver health and disease prevention.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver diseases related to alcohol consumption and metabolic disorders.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of liver injury related to alcohol, indicating that this approach has potential for success.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Mishra, Lopa — Feinstein Institute for Medical Research
- Study coordinator: Mishra, Lopa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.