Investigating how certain proteins affect inflammation and cell death in Alzheimer's disease
Molecular mechanisms of gasdermin recognition by proteases and autophagy proteins in cytokine release
['FUNDING_P01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10861069
This study is looking at how certain proteins in the body might cause inflammation in Alzheimer's disease, with the hope of finding new ways to help treat the condition.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10861069 on ClinicalTrials.gov |
What this research studies
This research explores the mechanisms by which specific proteins, known as gasdermin D and caspases, contribute to the release of inflammatory substances in conditions like Alzheimer's disease. It focuses on understanding both the traditional and novel ways these proteins operate, particularly how they can trigger cell death or facilitate the release of cytokines without causing cell damage. By examining these processes, the research aims to uncover new insights into the immune responses involved in Alzheimer's and related disorders, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurological conditions or those not diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation and cell death in Alzheimer's disease, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammasomes and cytokines in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIAO, TSAN SAM — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: XIAO, TSAN SAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease