Investigating how certain proteins affect DNA repair processes
Official title: Understanding post translational modifiers in DNA damage repair
Funded at University of Texas Hlth Science Center · NIH-11059863 · Data updated 2026-11-12
This study is looking at how a protein called EYA4 helps fix DNA damage caused by things like radiation and pollution, and it aims to find ways to improve this repair process, which could help lower the risk of cancer and other genetic issues for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $193,750 |
| NIH project number | 5R21ES035997-02 |
| Project ID | NIH-11059863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of exposure to environmental agents that can cause DNA damage, such as heavy metals or radiation.
✕Less likely to help
Patients with genetic conditions unrelated to DNA damage repair mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding how specific proteins, particularly those involved in the repair of DNA damage, are regulated by chemical modifications. It examines the role of a protein called EYA4, which is crucial for repairing harmful DNA breaks caused by environmental factors like radiation and pollutants. By studying how EYA4 interacts with other proteins in the DNA damage response, the research aims to uncover new insights into the mechanisms that maintain genome stability and prevent diseases such as cancer. Patients may benefit from this research as it could lead to improved strategies for enhancing DNA repair in cells, potentially reducing the risk of cancer and other genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance DNA repair mechanisms, reducing the risk of cancer and other genetic diseases.
How similar studies have gone: Previous research has shown that understanding protein modifications in DNA repair can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Dray, Eloise — University of Texas Hlth Science Center
- Study coordinator: Dray, Eloise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.