Investigating how certain proteins affect DNA repair processes
Understanding post translational modifiers in DNA damage repair
['FUNDING_R21'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11059863
This study is looking at how a protein called EYA4 helps fix DNA damage caused by things like radiation and pollution, and it aims to find ways to improve this repair process, which could help lower the risk of cancer and other genetic issues for patients.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11059863 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific proteins, particularly those involved in the repair of DNA damage, are regulated by chemical modifications. It examines the role of a protein called EYA4, which is crucial for repairing harmful DNA breaks caused by environmental factors like radiation and pollutants. By studying how EYA4 interacts with other proteins in the DNA damage response, the research aims to uncover new insights into the mechanisms that maintain genome stability and prevent diseases such as cancer. Patients may benefit from this research as it could lead to improved strategies for enhancing DNA repair in cells, potentially reducing the risk of cancer and other genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of exposure to environmental agents that can cause DNA damage, such as heavy metals or radiation.
Not a fit: Patients with genetic conditions unrelated to DNA damage repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance DNA repair mechanisms, reducing the risk of cancer and other genetic diseases.
How similar studies have performed: Previous research has shown that understanding protein modifications in DNA repair can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRAY, ELOISE — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: DRAY, ELOISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.