Investigating how certain proteins affect cholesterol and fat metabolism in the body
The Nuclear Receptor-Aster Pathway in Enterohepatic Metabolism
This study is looking at how certain proteins called Asters help manage cholesterol and fat in the liver and intestines, which could lead to better treatments for diabetes and cancer, ultimately helping patients with metabolic disorders feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10873361 on NIH RePORTER |
What this research studies
This research explores the role of specific proteins, known as Asters, in regulating cholesterol and fat metabolism within the liver and intestines. By activating nuclear hormone receptors, these proteins help control how lipids are processed in the body, which is crucial for maintaining healthy cholesterol levels. The study aims to understand how these proteins contribute to conditions like diabetes and cancer, and how they might be targeted for new treatments. Patients may benefit from insights that could lead to improved therapies for metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders such as diabetes, non-alcoholic steatohepatitis (NASH), or those at risk for related conditions.
Not a fit: Patients who do not have metabolic disorders or related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic diseases linked to cholesterol and fat metabolism.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism and its implications for metabolic diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Tontonoz, Peter J — University of California Los Angeles
- Study coordinator: Tontonoz, Peter J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.