Investigating how certain proteins affect cancer growth through gene regulation.
Epigenetic modulation of the TAZ-CAMTA1 transcriptional program by the Ada2a-containing histone acetyltransferase complex
This study is looking at how two proteins, TAZ and YAP, affect the growth and spread of a rare cancer called epithelioid hemangioendothelioma, and it aims to find new ways to treat this cancer by understanding how these proteins are controlled in our cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10754856 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific proteins, TAZ and YAP, in the development and spread of various cancers, particularly a type of sarcoma known as epithelioid hemangioendothelioma. The study aims to explore how these proteins are regulated at the epigenetic level, which involves changes in gene expression without altering the DNA sequence. By using advanced techniques like mass spectrometry and genetic screening, the researchers will identify key proteins that influence the cancer-driving effects of TAZ and YAP. This could lead to new insights into cancer treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epithelioid hemangioendothelioma or other cancers involving TAZ and YAP alterations.
Not a fit: Patients with cancers unrelated to TAZ and YAP or those without genetic alterations in these pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating aggressive cancers, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting epigenetic regulation in cancer, suggesting potential for success in this approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Tanas, Munir — University of Iowa
- Study coordinator: Tanas, Munir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.