Investigating how certain proteins affect brain signaling in autism.
Functional Mapping of Chd1-dependent Signaling Network in Synaptic Homeostasis
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-11138643
This study is looking at how certain proteins in the brain might affect the way connections between brain cells work in people with autism, with the hope of finding new ways to help improve their development and behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11138643 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of chromatin remodeling proteins and synaptic molecules in autism spectrum disorder (ASD). By examining how these proteins influence synaptic homeostasis, the study aims to uncover the molecular mechanisms that contribute to the development of ASD. The approach involves genetic studies and analysis of neuronal function to identify how disruptions in these proteins may lead to behavioral and developmental challenges in individuals with ASD. Patients may benefit from insights that could lead to new therapeutic strategies targeting these underlying biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with comorbid conditions.
Not a fit: Patients without a diagnosis of autism spectrum disorder or related neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for individuals with autism spectrum disorder.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and molecular underpinnings of autism, suggesting that this approach could yield valuable insights.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, TINGTING — GEORGETOWN UNIVERSITY
- Study coordinator: WANG, TINGTING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention deficit hyperactivity disorder, autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder