Investigating how certain proteins affect brain signaling in autism.
Official title: Functional Mapping of Chd1-dependent Signaling Network in Synaptic Homeostasis
Funded at Georgetown University · NIH-11138643 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain might affect the way connections between brain cells work in people with autism, with the hope of finding new ways to help improve their development and behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | July 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $332,011 |
| NIH project number | 5R01MH134978-02 |
| Project ID | NIH-11138643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with comorbid conditions.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or related neurodevelopmental disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of chromatin remodeling proteins and synaptic molecules in autism spectrum disorder (ASD). By examining how these proteins influence synaptic homeostasis, the study aims to uncover the molecular mechanisms that contribute to the development of ASD. The approach involves genetic studies and analysis of neuronal function to identify how disruptions in these proteins may lead to behavioral and developmental challenges in individuals with ASD. Patients may benefit from insights that could lead to new therapeutic strategies targeting these underlying biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for individuals with autism spectrum disorder.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and molecular underpinnings of autism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Wang, Tingting — Georgetown University
- Study coordinator: Wang, Tingting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.