Investigating how certain proteins affect brain immune cells in aging and neurodegenerative diseases
Official title: Perturbing the LXR/SREBP axis to decipher protective and pathogenic AD/ADRD microglial phenotypes
Funded at University of California, San Diego · NIH-10883959 · Data updated 2026-11-12
This study is looking at how certain proteins in brain immune cells, called microglia, can either help or hurt the brain in diseases like Alzheimer's, and it aims to find ways to improve their protective functions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $3,840,870 |
| NIH project number | 1RF1AG083977-01A1 |
| Project ID | NIH-10883959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing neurodegenerative diseases, particularly those related to aging, such as Alzheimer's disease.
✕Less likely to help
Patients with acute neurological conditions or those not affected by neurodegenerative diseases may not benefit from this research.
What this research studies
This research explores the dual roles of microglia, the brain's immune cells, in neurodegenerative diseases, focusing on how specific proteins influence their behavior. By examining the effects of lipid metabolism and the accumulation of lipid droplets, the study aims to understand the mechanisms that lead to either protective or harmful microglial functions. The researchers will utilize genetic and molecular techniques to manipulate these proteins and observe the resulting changes in microglial activity, which could provide insights into potential therapeutic targets for conditions like Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the protective functions of microglia, potentially slowing the progression of neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in manipulating similar pathways in animal models, suggesting potential for success in this approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Glass, Christopher K — University of California, San Diego
- Study coordinator: Glass, Christopher K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.