Investigating how certain proteins affect brain cell movement during development
Neurodevelopmental Disorder-Associated Rho Regulators in Neocortical Development
['FUNDING_R01'] · COLD SPRING HARBOR LABORATORY · NIH-10795027
This study is looking at how a special protein helps important brain cells move to the right spots during brain development, which could help us understand why some people have cognitive issues or epilepsy, and hopefully lead to better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-10795027 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the migration of neocortical pyramidal neurons, which are essential for higher-order brain functions. It examines the role of a specific protein, oligophrenin-1, in guiding these neurons to their correct positions in the developing brain. By studying the molecular mechanisms involved, the research aims to uncover how disruptions in this process can lead to neurodevelopmental disorders, such as cognitive impairments and epilepsy. Patients may benefit from insights gained into the causes of these disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those linked to cognitive impairments and epilepsy.
Not a fit: Patients with neurodevelopmental disorders not associated with the migration of neocortical pyramidal neurons may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders that affect cognition and behavior.
How similar studies have performed: Previous research has shown success in understanding the role of molecular mechanisms in neuron migration, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN AELST, LINDA — COLD SPRING HARBOR LABORATORY
- Study coordinator: VAN AELST, LINDA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Disorders, Encephalon Diseases