Investigating how certain proteins affect B cell function in autoimmune diseases
Official title: Novel unconventional myosins in B cell homeostasis
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11109616 · Data updated 2026-11-12
This study is looking at a protein called Myo18A to see how it affects B cells, which are important for our immune system, and it aims to find new ways to help people with autoimmune diseases where these B cells are too active.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $529,302 |
| NIH project number | 5R01AI172916-03 |
| Project ID | NIH-11109616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune diseases characterized by dysregulated B cell activity.
✕Less likely to help
Patients with autoimmune diseases not primarily driven by B cell dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, Myo18A, in the survival and activation of B cells, which are crucial in the immune response. By analyzing how Myo18A influences B cell behavior, the study aims to uncover mechanisms that lead to autoimmune diseases characterized by excessive B cell activation and autoantibody production. The research involves examining gene expression and cellular responses in B cells lacking Myo18A to identify potential therapeutic targets for improving patient outcomes in autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better regulate B cell activity, potentially reducing the severity of autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in targeting B cell regulation for treating autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Gupta, Neetu — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Gupta, Neetu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.