Investigating how certain proteins affect B cell function in autoimmune diseases
Novel unconventional myosins in B cell homeostasis
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11109616
This study is looking at a protein called Myo18A to see how it affects B cells, which are important for our immune system, and it aims to find new ways to help people with autoimmune diseases where these B cells are too active.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11109616 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific protein, Myo18A, in the survival and activation of B cells, which are crucial in the immune response. By analyzing how Myo18A influences B cell behavior, the study aims to uncover mechanisms that lead to autoimmune diseases characterized by excessive B cell activation and autoantibody production. The research involves examining gene expression and cellular responses in B cells lacking Myo18A to identify potential therapeutic targets for improving patient outcomes in autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from autoimmune diseases characterized by dysregulated B cell activity.
Not a fit: Patients with autoimmune diseases not primarily driven by B cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better regulate B cell activity, potentially reducing the severity of autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in targeting B cell regulation for treating autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUPTA, NEETU — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: GUPTA, NEETU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.