Investigating how certain proteins affect autoimmune neuroinflammation in multiple sclerosis
Official title: STAT5 Tetramerization in Autoimmune-mediated Neuroinflammation
Funded at West Virginia University · NIH-11012300 · Data updated 2026-11-12
This study is looking at how a protein called STAT5 affects the immune system in multiple sclerosis, using a special mouse model to learn more about how it might lead to new treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project start | January 17, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $496,195 |
| NIH project number | 5R01AI167972-02 |
| Project ID | NIH-11012300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis or those at risk of developing the condition.
✕Less likely to help
Patients with other neurological disorders unrelated to autoimmune mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins, known as STAT5, in the immune response that leads to multiple sclerosis (MS). By using a special mouse model that prevents the formation of certain protein structures, researchers aim to uncover how these proteins influence the interactions between immune cells in the central nervous system. The goal is to identify key signaling pathways that contribute to the inflammation and damage seen in MS, which could lead to new therapeutic strategies. Patients may benefit from insights gained about the mechanisms of MS and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating multiple sclerosis.
How similar studies have gone: Previous research has shown promising results in understanding immune mechanisms in multiple sclerosis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
West Virginia University
Morgantown, United States Active
Researchers
- Principal investigator: Wan, Edwin Chi Keung — West Virginia University
- Study coordinator: Wan, Edwin Chi Keung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.