Investigating how certain proteins affect addiction to stimulants and opioids
Transcription Factors in Stimulant and Opioid Action
This study is looking at how certain proteins in the brain affect how stimulants and opioids work, with the hope of finding new ways to help people struggling with addiction.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10934810 on NIH RePORTER |
What this research studies
This research explores the role of specific transcription factors in the brain that influence the effects of stimulants and opioids. By analyzing large datasets from both rodent models and humans with substance use disorders, the study aims to identify key proteins that contribute to addiction. The researchers are particularly focused on a protein called RXRa, which has shown promise in mediating drug actions and could lead to new treatment options. Patients may benefit from insights gained about how these proteins function and how they can be targeted for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with opioid or stimulant addiction.
Not a fit: Patients who do not have a history of substance use disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for opioid and stimulant addiction by targeting specific proteins in the brain.
How similar studies have performed: Previous research has successfully identified key proteins involved in addiction, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Nestler, Eric J. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Nestler, Eric J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.