Investigating how certain protein complexes affect our body's internal clock and health.
Potential Role of Compass H3K4 Methyltransferase Complexes in Environmental Circadian-Alignment
['FUNDING_OTHER'] · MOREHOUSE SCHOOL OF MEDICINE · NIH-10875599
This study is looking at how things like working night shifts or traveling across time zones affect our body's natural clock and health, especially focusing on certain proteins that help control our genes, to see if understanding this can help reduce the risk of diseases like breast cancer and heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MOREHOUSE SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10875599 on ClinicalTrials.gov |
What this research studies
This research explores the impact of environmental factors like shift work and jet lag on our body's circadian rhythms and overall health. It focuses on specific protein complexes known as COMPASS, which play a role in regulating gene expression by modifying histones, a type of protein that helps package DNA. By understanding how these complexes respond to environmental cues, the research aims to uncover their potential link to diseases such as breast cancer and cardiovascular disorders. Patients may benefit from insights into how lifestyle changes could mitigate health risks associated with circadian disruptions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing circadian disruptions due to shift work, jet lag, or other lifestyle factors.
Not a fit: Patients who do not experience circadian rhythm disruptions or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing diseases linked to circadian misalignment.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in health, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- MOREHOUSE SCHOOL OF MEDICINE — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUONG, HAO — MOREHOUSE SCHOOL OF MEDICINE
- Study coordinator: DUONG, HAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancer Causing Agents, Cancers, Cardiovascular Diseases