Investigating how certain pesticides may affect ADHD through genetic interactions
Gene-pesticide interactions and ADHD
This study is looking at how certain pesticides might make ADHD symptoms worse by examining genetically modified rats, and it aims to help us understand the connection between genes and the environment for people with ADHD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10871821 on NIH RePORTER |
What this research studies
This research explores the relationship between genetic factors and environmental influences, specifically how certain pesticides may exacerbate symptoms of Attention Deficit Hyperactivity Disorder (ADHD). By studying genetically modified rats, researchers aim to understand how the Latrophilin-3 gene interacts with pesticides like deltamethrin to influence behavior and cognitive function. The study involves assessing various behavioral and neurochemical responses in these animal models to draw parallels to human ADHD symptoms. The findings could provide insights into the biological mechanisms behind ADHD and the impact of environmental toxins.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adults diagnosed with ADHD, particularly those who may have been exposed to pesticides.
Not a fit: Patients without a diagnosis of ADHD or those who have not been exposed to relevant environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of ADHD, potentially informing prevention strategies related to environmental exposures.
How similar studies have performed: Previous research has indicated that environmental factors can influence neurodevelopmental disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Vorhees, Charles V — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Vorhees, Charles V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.