Investigating how certain non-coding RNAs affect drug metabolism in cancer treatment
A novel lncRNA-responsive and xenobiotic receptor-mediated regulation of drug metabolism and disposition
This study is looking at how certain molecules in our cells, called lncRNAs, might help explain why some cancer treatments don’t work as well as they should, with the hope that this information can lead to better ways to overcome treatment resistance for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11001135 on NIH RePORTER |
What this research studies
This research explores the role of long non-coding RNAs (lncRNAs) in regulating drug metabolism and disposition, particularly in the context of cancer chemotherapy. By analyzing data from 505 cancer cell lines, the study aims to identify specific lncRNAs that contribute to chemotherapy resistance by affecting drug-metabolizing enzymes and transporters. Patients may benefit from insights gained about how to improve the effectiveness of cancer treatments by overcoming drug resistance. The research employs integrative genomic analysis and high-throughput drug screening to uncover these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are undergoing chemotherapy and may be experiencing resistance to treatment.
Not a fit: Patients who are not currently undergoing chemotherapy or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatment strategies by identifying ways to overcome drug resistance.
How similar studies have performed: Other research has shown promising results in understanding the role of non-coding RNAs in drug metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Yang, Da — University of Pittsburgh at Pittsburgh
- Study coordinator: Yang, Da
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.