Investigating how certain molecules can regulate HCN channels in the body
Allosteric Modulation of HCN Channels
This study is looking for natural substances that can help control certain channels in your heart and brain, which could lead to better treatments for heart failure, epilepsy, and bladder issues, making medications more effective for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10909165 on NIH RePORTER |
What this research studies
This research focuses on hyperpolarization-activated cyclic nucleotide-sensitive (HCN) channels, which play a crucial role in controlling the electrical activity of various cells, including those in the heart and brain. The project aims to identify natural molecules that can specifically regulate these channels, potentially leading to new treatments for conditions like heart failure, epilepsy, and bladder dysfunction. By understanding how these regulators work, the research hopes to pave the way for the development of more effective and targeted medications. Patients may benefit from improved therapies that are tailored to their specific conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from conditions such as heart failure, epilepsy, neuropathic pain, or bladder dysfunction.
Not a fit: Patients with conditions unrelated to HCN channel dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new, more effective medications for a variety of serious health conditions.
How similar studies have performed: Previous research has shown promise in targeting HCN channels for therapeutic purposes, indicating that this approach could lead to significant advancements.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Proenza, Catherine — University of Colorado Denver
- Study coordinator: Proenza, Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.