Investigating how certain molecules affect the formation and healing of dental cementum.
Role of modulators of Pi/PPi in cementum formation and regeneration
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10687850
This study is looking at how a substance called pyrophosphate and its helpers affect the growth and repair of cementum, an important part of your teeth, to find new ways to help people with gum disease and other dental issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10687850 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of pyrophosphate and its regulators in the formation and regeneration of cementum, a vital tissue in the dental structure. By studying the interactions between specific proteins that manage pyrophosphate levels, the research aims to uncover how these processes affect dental health, particularly in conditions like periodontal disease. Patients may benefit from insights that could lead to new therapies for mineralization disorders affecting their teeth and gums.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting pyrophosphate regulation, leading to dental issues.
Not a fit: Patients without any dental or genetic conditions related to cementum formation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for dental conditions that involve abnormal cementum formation.
How similar studies have performed: Previous research has shown promising results in understanding the role of pyrophosphate in mineralization, indicating potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHU, EMILY YIN — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: CHU, EMILY YIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.