Investigating how certain molecules affect tendon damage and healing in older adults
Official title: Glycosaminoglycan-mediated fibril sliding and its role in fatigue-induced microdamage and rupture in aged and healing Achilles tendons
Funded at University of Pennsylvania · NIH-10823565 · Data updated 2026-11-12
This study is looking at how certain natural substances in our bodies, called glycosaminoglycans (GAGs), can help keep Achilles tendons strong and healthy, especially when they’re tired or healing, to better understand how to prevent injuries and improve recovery for people with tendon issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 11, 2024 |
| Project end | September 10, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,828 |
| NIH project number | 1F32AR082671-01A1 |
| Project ID | NIH-10823565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults or individuals recovering from Achilles tendon injuries.
✕Less likely to help
Patients with acute tendon injuries or those who do not have any tendon-related issues may not benefit from this research.
What this research studies
This research explores the role of glycosaminoglycans (GAGs) in the health of Achilles tendons, particularly how they may help prevent damage caused by fatigue. By examining the interactions between GAGs and collagen fibrils in both aging and healing tendons, the study aims to understand how these molecules can influence tendon strength and resilience. The research employs advanced techniques to analyze tendon mechanics and the effects of GAGs on load-bearing capabilities, which could lead to new insights into tendon injuries and recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for tendon injuries, particularly in older adults.
How similar studies have gone: Previous research has indicated that understanding the role of GAGs in tendon mechanics could lead to significant advancements in tendon injury prevention and treatment.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Blank, Jonathon — University of Pennsylvania
- Study coordinator: Blank, Jonathon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.