Investigating how certain microRNAs affect energy production in fat cells
miR-27 mediated regulation of mitochondrial function in thermogenic adipocytes
This study is looking at how certain tiny molecules called microRNAs affect special fat cells that help burn energy and keep us warm, with the hope of finding new ways to fight obesity and related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11086833 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific microRNAs, particularly miR-27a/b, in regulating the function of beige adipocytes, which are fat cells that help burn energy and generate heat. By using a model of beige adipocyte differentiation from human stem cells, the researchers aim to explore how these microRNAs influence mitochondrial function and thermogenesis. The study seeks to uncover mechanisms that could enhance the activation of beige adipocytes, potentially providing new insights into combating obesity and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are overweight or obese and may be at risk for type 2 diabetes.
Not a fit: Patients who are underweight or have conditions unrelated to obesity or metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating obesity and reducing the risk of type 2 diabetes by enhancing energy expenditure in fat cells.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in metabolic processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Mainehealth — Portland, United States (Active)
Researchers
- Principal investigator: Brown, Aaron Clifford — Mainehealth
- Study coordinator: Brown, Aaron Clifford
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.