Investigating how certain metabolites affect inflammation and brain energy in older adults with delirium
Geroscience metabolites beta-hydroxybutyrate and NAD+ linking inflammation and neuroenergetic failure in delirium
['FUNDING_R01'] · BUCK INSTITUTE FOR RESEARCH ON AGING · NIH-10833601
This study is looking at how brain inflammation and energy problems might cause confusion in older adults with Alzheimer's and similar conditions, and it’s exploring whether using ketone bodies could help provide energy to the brain and reduce delirium.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BUCK INSTITUTE FOR RESEARCH ON AGING (nih funded) |
| Locations | 1 site (NOVATO, UNITED STATES) |
| Trial ID | NIH-10833601 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding delirium, a common condition in older adults characterized by confusion, especially in those with Alzheimer's Disease and Related Dementias (ADRD). The study aims to explore the connection between neuroinflammation and energy disruption in the brain, using innovative methods including cell systems, mouse models, and human biospecimens. By examining how ketone bodies can serve as an alternative energy source for the brain, the research seeks to uncover potential therapeutic strategies to mitigate delirium and its associated risks.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those with Alzheimer's Disease or related dementias who are at risk for delirium.
Not a fit: Patients who are younger or do not have cognitive impairments or risk factors for delirium may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the incidence of delirium and improve cognitive outcomes for older adults.
How similar studies have performed: Previous research has shown promising results with ketogenic diets improving memory in aging models, indicating potential success for similar approaches in this study.
Where this research is happening
NOVATO, UNITED STATES
- BUCK INSTITUTE FOR RESEARCH ON AGING — NOVATO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEWMAN, JOHN C — BUCK INSTITUTE FOR RESEARCH ON AGING
- Study coordinator: NEWMAN, JOHN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia