Investigating how certain medications may reduce alcohol consumption in rodents
Establishing the Molecular Mechanisms of Reduced Ethanol Drinking in Calcineurin-Mediated Immunosuppression Treated Rodents
This study is looking at how certain medications that help liver transplant patients might also change how much alcohol they drink, hoping to find new ways to help people with drinking problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10847322 on NIH RePORTER |
What this research studies
This research explores the effects of immunosuppressant medications on alcohol consumption in rodent models. It aims to understand how these medications, commonly used in liver transplant patients, might lead to reduced drinking behavior. By examining the role of calcineurin, a protein in the brain, the study seeks to uncover the biological mechanisms that could explain why some individuals stop drinking after receiving a liver transplant. The findings could provide insights into new treatment options for alcohol use disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder, particularly those who may benefit from new therapeutic approaches.
Not a fit: Patients who do not have alcohol use disorders or those not receiving immunosuppressant medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for individuals struggling with alcohol use disorders.
How similar studies have performed: While this approach is novel in its specific focus on immunosuppressants and alcohol consumption, similar studies have shown promise in understanding the biological mechanisms behind addiction.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Beresford, Thomas P — VA Eastern Colorado Health Care System
- Study coordinator: Beresford, Thomas P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.