Investigating how certain medications affect the closure of a vital blood vessel in newborns
Pharmacologic Contributors to Patent Ductus Arteriosus
This study is looking at how certain medications given to premature babies in the neonatal intensive care unit might affect the closing of a vital blood vessel called the ductus arteriosus, which should close after birth, to help find better ways to treat any problems that arise if it doesn't close properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10864055 on NIH RePORTER |
What this research studies
This research focuses on understanding how various medications used in neonatal intensive care units may impact the closure of the ductus arteriosus (DA), a crucial blood vessel that should close after birth. The study aims to identify specific drugs that may inadvertently prevent this closure, leading to a condition known as patent ductus arteriosus (PDA), which can be serious for premature infants. By analyzing the effects of commonly used medications, including antibiotics and antacids, the researchers hope to uncover new insights into the mechanisms behind PDA and develop better treatment strategies. The approach involves both laboratory studies and analysis of patient data to evaluate the pharmacological influences on DA closure.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill preterm infants who are receiving medications in a neonatal intensive care setting.
Not a fit: Patients who are not newborns or those who do not require intensive care for conditions related to ductus arteriosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for preventing patent ductus arteriosus in vulnerable newborns.
How similar studies have performed: While the specific approach of this research is novel, previous studies have indicated that medications can influence vascular responses in newborns, suggesting potential for impactful findings.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Reese, John Jeffrey — Vanderbilt University Medical Center
- Study coordinator: Reese, John Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.