Investigating how certain macrophage microRNAs affect fat cell development
Macrophage miR-130b/301b and beige adipogenesis
This study is looking at how tiny molecules made by immune cells can help turn fat cells into a healthier type that helps manage weight, with the hope of finding new ways to treat obesity and related health issues like type 2 diabetes and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11064018 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific microRNAs produced by macrophages in the development of beige adipocytes, which are important for regulating energy balance and combating obesity. By studying how these microRNAs influence the transformation of fat cells, the research aims to uncover new therapeutic targets for obesity-related conditions such as type 2 diabetes and cardiovascular diseases. The approach includes both animal models and human tissue samples to explore the mechanisms of adipose tissue remodeling and energy metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or related metabolic disorders, particularly those with type 2 diabetes.
Not a fit: Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to burn fat and improve metabolic health.
How similar studies have performed: Previous research has shown promising results in targeting adipocyte development for obesity treatment, indicating that this approach may lead to significant advancements.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Jiang, Shaoning — Yale University
- Study coordinator: Jiang, Shaoning
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.