Investigating how certain macrophage microRNAs affect fat cell development
Official title: Macrophage miR-130b/301b and beige adipogenesis
Funded at Yale University · NIH-11064018 · Data updated 2026-11-12
This study is looking at how tiny molecules made by immune cells can help turn fat cells into a healthier type that helps manage weight, with the hope of finding new ways to treat obesity and related health issues like type 2 diabetes and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $451,232 |
| NIH project number | 5R01DK138986-02 |
| Project ID | NIH-11064018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or related metabolic disorders, particularly those with type 2 diabetes.
✕Less likely to help
Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific microRNAs produced by macrophages in the development of beige adipocytes, which are important for regulating energy balance and combating obesity. By studying how these microRNAs influence the transformation of fat cells, the research aims to uncover new therapeutic targets for obesity-related conditions such as type 2 diabetes and cardiovascular diseases. The approach includes both animal models and human tissue samples to explore the mechanisms of adipose tissue remodeling and energy metabolism.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to burn fat and improve metabolic health.
How similar studies have gone: Previous research has shown promising results in targeting adipocyte development for obesity treatment, indicating that this approach may lead to significant advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Jiang, Shaoning — Yale University
- Study coordinator: Jiang, Shaoning
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.