Investigating how certain lipids predict the risk of developing diabetes
Ceramides and Sphingolipids as Predictors of Incident Dysglycemia
This study is looking at how certain fats in the body might help us understand why some people develop prediabetes or type 2 diabetes, and it's for folks who don’t have a family history of diabetes to see how their body reacts differently.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10809770 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific bioactive lipids, particularly ceramides and sphingolipids, in the progression from normal glucose regulation to type 2 diabetes (T2D). By analyzing stored blood samples from participants with varying histories of diabetes, the study aims to identify how these lipids may influence the onset of prediabetes and T2D. Participants will include individuals with no family history of diabetes, allowing for a comparison between those who develop prediabetes and those who do not. The findings could provide insights into early biomarkers for diabetes risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are normoglycemic and have no family history of diabetes.
Not a fit: Patients who are already diagnosed with type 2 diabetes or have a strong family history of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of individuals at risk for type 2 diabetes, allowing for timely interventions.
How similar studies have performed: Previous research has shown promising results in linking bioactive lipids to diabetes risk, suggesting that this approach may yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Dagogo-Jack, M.d., D.sc., Samuel — University of Tennessee Health Sci Ctr
- Study coordinator: Dagogo-Jack, M.d., D.sc., Samuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.