Investigating how certain lipids affect heart development in congenital heart disease.
Oxylipin Signaling in Congenital Heart Disease
This study is looking at how certain natural fats in our bodies might affect heart development in babies with congenital heart defects, using tiny heart models made from human stem cells to see if diet can play a role in preventing these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10993124 on NIH RePORTER |
What this research studies
This research focuses on understanding congenital heart defects (CHD), which are the most common type of birth defect. It explores the role of oxylipins, a class of bioactive lipids, in heart development and how their signaling pathways may contribute to CHD. The researchers will use human stem cell-derived cardiac organoids to study the mechanisms of oxylipin signaling and its effects on heart formation. By examining these pathways, the study aims to uncover potential dietary influences on heart development.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital heart defects or those at risk of developing them.
Not a fit: Patients with congenital heart defects caused by genetic mutations unrelated to oxylipin signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating congenital heart defects.
How similar studies have performed: While the role of oxylipins in cardiovascular health is being explored, this specific approach to studying their impact on congenital heart disease is relatively novel.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Aguirre, Aitor — Michigan State University
- Study coordinator: Aguirre, Aitor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.