Investigating how certain lipids affect blood vessel function in stroke.
Endothelial Sphingolipid Signaling in Neurovascular Ischemic Injury
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10821399
This study is looking at how certain fats in the body, called sphingolipids, affect blood vessels during a stroke, with the hope of finding new ways to help patients recover better and reduce damage after a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10821399 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of sphingolipids, particularly sphingosine-1-phosphate (S1P), in the function of blood vessels during stroke. It aims to uncover how these lipids influence the blood-brain barrier and contribute to neurovascular injury. By studying the molecular mechanisms involved, the research seeks to identify potential therapeutic targets that could minimize damage and improve recovery after a stroke. Patients may benefit from new treatments that specifically target endothelial function and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke or are at high risk for stroke.
Not a fit: Patients with conditions unrelated to stroke or those who have not experienced any cerebrovascular events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that protect the brain from damage during strokes.
How similar studies have performed: Other research has shown promising results in targeting endothelial signaling pathways for therapeutic benefits in various conditions, suggesting potential for success in this area as well.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANCHEZ GARCIA-VAO, TERESA — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: SANCHEZ GARCIA-VAO, TERESA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.