Investigating how certain ion channels help protect kidney blood vessels from injury.
Official title: Degenerin and TrpC6 channels in renal vascular mechanosesnsor signaling and protection against injury.
Funded at University of Mississippi Med Ctr · NIH-11059123 · Data updated 2026-11-12
This study is looking at how certain channels in the blood vessels of the kidneys react to changes in pressure, which is important for keeping blood flow healthy and preventing kidney problems, and it involves experiments with animals to learn more about these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $598,007 |
| NIH project number | 5R01DK137167-02 |
| Project ID | NIH-11059123 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for chronic kidney disease, particularly those with conditions that affect blood pressure regulation.
✕Less likely to help
Patients with acute kidney injury or those who do not have any underlying kidney conditions may not benefit from this research.
What this research studies
This research focuses on understanding how specific ion channels in kidney blood vessels respond to pressure changes, which is crucial for maintaining healthy blood flow and preventing damage. By examining the roles of different ion channels, including b/gENaC-ASIC2 and TrpC6, the study aims to uncover the mechanisms that allow blood vessels to constrict in response to high pressure. This could lead to insights into how the loss of this response contributes to kidney disease progression. The research involves laboratory experiments using animal models to explore these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting kidney function and preventing chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding mechanosensing in vascular systems, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Drummond, Heather a — University of Mississippi Med Ctr
- Study coordinator: Drummond, Heather a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.