Investigating how certain immune cells respond to ozone exposure in the lungs
Official title: Understanding the role of myeloid cells in ozone-induced airway disease
Funded at North Carolina State University Raleigh · NIH-11014037 · Data updated 2026-11-12
This study is looking at how certain immune cells in our bodies can cause lung problems when we're exposed to ozone, especially for kids and older adults, with the goal of finding better treatments for breathing issues related to this pollution.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | February 13, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $503,969 |
| NIH project number | 7R01ES030125-05 |
| Project ID | NIH-11014037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living in areas with high ozone levels, particularly children, the elderly, and those with pre-existing respiratory conditions.
✕Less likely to help
Patients who do not live in areas with elevated ozone levels or who do not have respiratory issues may not benefit from this research.
What this research studies
This research focuses on understanding how myeloid cells, a type of immune cell, contribute to lung damage caused by ozone exposure. It aims to identify the specific roles of these cells in triggering inflammatory responses that can lead to respiratory issues, particularly in vulnerable populations such as children and the elderly. By examining the cellular and molecular mechanisms involved, the research seeks to develop targeted therapies that can more effectively treat ozone-induced airway diseases. The study will involve analyzing the interactions between myeloid cells and other immune cells to better understand the pathways that lead to inflammation and lung injury.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for respiratory diseases caused by ozone exposure.
How similar studies have gone: Previous research has shown that targeting specific immune pathways can lead to significant improvements in treating allergic asthma and related conditions, suggesting potential success for this approach.
Where this research is happening
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North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Saini, Yogesh — North Carolina State University Raleigh
- Study coordinator: Saini, Yogesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.