Investigating how certain immune cells protect nerve cells after eye injuries
Official title: Arginase positive monocyte mediated RGC neuroprotection after traumatic optic neuropathy
Funded at Ohio State University · NIH-10882564 · Data updated 2026-11-12
This study is looking at how certain immune cells can help heal and protect the nerve cells in the eye after injuries, with the hope of finding new ways to improve recovery for people with optic nerve damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 29, 2029 |
| Funding year | 2024 |
| Award (this year) | $458,517 |
| NIH project number | 1R01EY035307-01A1 |
| Project ID | NIH-10882564 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals who have experienced traumatic optic neuropathy or similar optic nerve injuries.
✕Less likely to help
Patients with chronic optic nerve damage or those who do not have a recent injury may not benefit from this research.
What this research studies
This research focuses on understanding how specific immune cells, particularly arginase positive monocytes and alternatively activated neutrophils, can help protect and repair retinal ganglion cells (RGCs) after traumatic injuries. By using animal models, the study aims to explore the mechanisms through which these immune cells contribute to neuroprotection and promote axon regeneration in the optic nerve. The goal is to identify potential therapeutic targets that could enhance recovery from optic nerve injuries and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and reduce disability for patients with optic nerve injuries.
How similar studies have gone: Previous studies have shown promise in using immune modulation for neuroprotection, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Sas, Andrew Robert — Ohio State University
- Study coordinator: Sas, Andrew Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.