Investigating how certain immune cells interact with prostate cancer in the bone.
Understanding the influence of bone-metastatic prostate cancer and mesenchymal stromal cells on γδ T cells, in the bone microenvironment.
This study is looking at how special immune cells can be changed to better fight prostate cancer that has spread to the bones, and it’s testing a drug to help make these immune cells even more effective, all with the goal of finding better treatments for patients with advanced prostate cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10798138 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific type of immune cell, called γδ T cells, interacts with bone-metastatic prostate cancer and mesenchymal stromal cells in the bone environment. The approach involves modifying these T cells to better target cancer cells and using a drug called zoledronate to enhance their effectiveness. By studying these interactions, the research aims to develop new immunotherapy strategies that could improve treatment outcomes for patients with advanced prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with castrate-resistant prostate cancer that has metastasized to the bone.
Not a fit: Patients with early-stage prostate cancer or those whose cancer has not spread to the bone may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with castrate-resistant prostate cancer that has spread to the bone.
How similar studies have performed: Other research has shown promise in using modified T cells for cancer treatment, suggesting that this approach could be effective, although the specific combination being tested here is novel.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Abate-Daga, Daniel — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Abate-Daga, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.