Investigating how certain immune cells interact with gut microbes and inflammation
Kruppel-like factor-2 CD4+ T cells and intestinal inflammation
This study is looking at how certain immune cells in your body react to helpful bacteria in your gut and how this affects inflammation, which could lead to new treatments for conditions like inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10914269 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific immune cells, particularly CD4+ T cells, respond to the presence of beneficial gut microbes and how this interaction can influence intestinal inflammation. By using advanced techniques like ATAC sequencing, the study aims to identify the mechanisms that allow the immune system to tolerate these microbes without triggering an inflammatory response. Patients may benefit from insights gained about the immune processes involved in conditions like inflammatory bowel disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with inflammatory bowel disease or other related autoimmune conditions.
Not a fit: Patients without any autoimmune conditions or gastrointestinal issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for inflammatory bowel disease and other autoimmune disorders.
How similar studies have performed: Previous research has shown promise in understanding immune responses to gut microbes, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Way, Sing Sing — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Way, Sing Sing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.